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bk channel activator ns1619  (Tocris)


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    Structured Review

    Tocris bk channel activator ns1619
    Bk Channel Activator Ns1619, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 18 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bk+channel+activator+ns1619/NS+1619/pm34008188-84-33-22
    Average 94 stars, based on 18 article reviews
    bk channel activator ns1619 - by Bioz Stars, 2026-09
    94/100 stars

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    Related Articles

    Incubation:

    Article Title: Transcriptome-based screening of ion channels and transporters in a migratory chondroprogenitor cell line isolated from late-stage osteoarthritic cartilage.
    Article Snippet: .. Before the assays, cells were incubated for 48 h in the presence of the selective BK channel blocker iberiotoxin (IBTX) (100 nM; Tocris; Bio‐Techne); the potent BK channel inhibitor paxilline (1 μM); the BK channel activator NS1619 (10 μM; Sigma‐Andrich); or vehicles at equal volumes (water, dimethyl sulfoxide and ethanol, respectively). ..



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    Effect of homocysteine (Hcy) on the relaxant response of internal mammary artery (IMA) to KCa channel activators. Hcy exposure significantly suppressed the BKCa channel activator <t>NS1619-induced</t> relaxation (A) whereas showed no influence on the IKCa/SKCa channel activator NS309-induced response (B). n=6. *P<0.05, ***P<0.001 vs. control.
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    Effect of homocysteine (Hcy) on the relaxant response of internal mammary artery (IMA) to KCa channel activators. Hcy exposure significantly suppressed the BKCa channel activator <t>NS1619-induced</t> relaxation (A) whereas showed no influence on the IKCa/SKCa channel activator NS309-induced response (B). n=6. *P<0.05, ***P<0.001 vs. control.
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    Effect of GM on <t>NS1619-activated</t> current (HP = −50 mV). ( A ) The NS1619-activated current was strongly blocked by 200 nM IBTX. In addition, 50 μM GM could not block the current induced by 30 μM NS1619, while 300 μM inhibited it slightly; ( B ) Bar histogram showed the effects of 200 nM IBTX, 50 μM GM, and 300 μM GM on the current evoked by 30 μM NS1619. Each point represents the mean ± SD of 5 cells.
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    Image Search Results


    Effect of homocysteine (Hcy) on the relaxant response of internal mammary artery (IMA) to KCa channel activators. Hcy exposure significantly suppressed the BKCa channel activator NS1619-induced relaxation (A) whereas showed no influence on the IKCa/SKCa channel activator NS309-induced response (B). n=6. *P<0.05, ***P<0.001 vs. control.

    Journal: Annals of Translational Medicine

    Article Title: Homocysteine alters vasoreactivity of human internal mammary artery by affecting the K Ca channel family

    doi: 10.21037/atm-20-6821

    Figure Lengend Snippet: Effect of homocysteine (Hcy) on the relaxant response of internal mammary artery (IMA) to KCa channel activators. Hcy exposure significantly suppressed the BKCa channel activator NS1619-induced relaxation (A) whereas showed no influence on the IKCa/SKCa channel activator NS309-induced response (B). n=6. *P<0.05, ***P<0.001 vs. control.

    Article Snippet: Cumulative dose-response curves were then established for (I) BK Ca channel activator NS1619 (−9–−4.5 LogM) (MedChemExpress, Cat#HY-12496), or (II) IK Ca /SK Ca channel activator NS309 (−9–−4.5 LogM) (MedChemExpress, Cat#HY-15416), or (III) acetylcholine (−10–−4.5LogM) (Sigma Aldrich, Cat#A6625) when the contraction reached a plateau.

    Techniques: Control

    Effect of GM on NS1619-activated current (HP = −50 mV). ( A ) The NS1619-activated current was strongly blocked by 200 nM IBTX. In addition, 50 μM GM could not block the current induced by 30 μM NS1619, while 300 μM inhibited it slightly; ( B ) Bar histogram showed the effects of 200 nM IBTX, 50 μM GM, and 300 μM GM on the current evoked by 30 μM NS1619. Each point represents the mean ± SD of 5 cells.

    Journal: International Journal of Molecular Sciences

    Article Title: Gentamicin Blocks the ACh-Induced BK Current in Guinea Pig Type II Vestibular Hair Cells by Competing with Ca 2+ at the l -Type Calcium Channel

    doi: 10.3390/ijms15046757

    Figure Lengend Snippet: Effect of GM on NS1619-activated current (HP = −50 mV). ( A ) The NS1619-activated current was strongly blocked by 200 nM IBTX. In addition, 50 μM GM could not block the current induced by 30 μM NS1619, while 300 μM inhibited it slightly; ( B ) Bar histogram showed the effects of 200 nM IBTX, 50 μM GM, and 300 μM GM on the current evoked by 30 μM NS1619. Each point represents the mean ± SD of 5 cells.

    Article Snippet: NS1619 (a BK channel activator) was formulated as a 10 mM stock solution in DMSO (Sigma, St. Louis, MO, USA). (−)-Bay-K8644 (the l -type calcium channel agonist) and nifedipine (a calcium channel blocker) were formulated as 10 mM stock solutions in DMSO and diluted for use.

    Techniques: Blocking Assay